RP1
RP2 Expanding systems biology with clinical phenomenology of AD to understand time and scale coupling using generative AI and supercomputing
Description:
Unlocking the Brain: A New Era in Fighting Neurodegenerative Disease
We're facing a massive challenge in the fight against diseases like Alzheimer's: the connections between tiny changes in your molecules and the big changes we see in your brain are incredibly complex. Existing theories, like the amyloid cascade or the calcium theory of aging, haven't been fully proven because it's so hard to link all the data together. This means we could be missing the most powerful targets for new therapies!
Our High-Tech Approach: Integrating Data to Find Cures
Our project is building a revolutionary new way to see the whole picture. We are developing sophisticated Generative and Predictive AI Models that can speak the language of many different data types all at once:
- Molecular Data: Understanding your genomics (DNA) and tiny biochemical processes.
- Whole-Brain Data: Analyzing detailed neuroimaging (MRIs), electrophysiology (EEGs), and cognitive assessments.
- Multiscale Integration: Combining this data to identify complex relationships across temporal and spatial scales.
By integrating these diverse sources, we are creating a high-performance computing (HPC) environment to:
- Establish a Timeline: Pinpoint the exact temporal sequence of events that lead to disease progression.
- Test the Theories: Fully evaluate the key hypotheses about the causes of diseases like Alzheimer's.
- Develop New Tools: Create tools for sharing and working with this data, promoting open science and collaborative discovery.
This powerful, data-driven approach will ultimately lead to precision medicine tools for personalized patient care, identify patients who will benefit from new therapies, and discover novel mechanisms for new diagnostics and therapeutic interventions.
Team members:
Vladimír Sladký (Senior operator - Researcher)
Michal Seják (Ph.D. Student - Researcher)
Dr. Olivier Colliot, Research director
Research Director at CNRS, co-head of the ARAMIS team
